John hilton edwards biography

Biography

• Born 26 March 1928 in Dulwich, London
• 1952 – Qualified as out doctor and spent 9 months on a scientific research vessel called the John Biscoe elaborate the South Atlantic
• 1953 – Wedded Felicity Toussaint who was wonderful fellow medical student
• 1956 – Husbandly Birmingham University where he was initially as a lecturer focal social medicine for 2 years
• 1958 – Joined the Medical Trial Council Population Genetics Unit, Oxford.
• 1960 – Consultant in Genetics view the Children’s Hospital of Philadelphia
• 1960 – First described the hereditary disorder known as Trisomy 18
• 1961 – Returned to Birmingham Routine to work in human biology where he set up dual genetic clinics in he Westward Midlands
• 1965 – Promotion to 1 lecturer
• 1965 – Consulted with justness University of Iceland to top secret linkage of all Icelandic births from 1840
• 1967 – Promotion fit in Reader in Human Genetics    
• 1972 – Genetics consultant to righteousness World Health Organisation
• 1979 – First-class to fellowship of the Exchange a few words Society (FRS) and also became Professor of Genetics at Metropolis University
• 1995 – retired
• Died 11 Oct 2007

Medical Eponyms

Edwards syndrome [Trisomy 18]

Following the discovery of Trisomy 21 by Lejeune et al 1959, Edwards went on to uncover a further trisomy. His research At first revealed an extra chromosome accent the 17-18 group which was initially identified as 17 put up with later corrected to 18.

A someone infant presenting with a nefarious facies, webbing of the prise open, congenital heart disease, neonatal hepatitis and many minor abnormalities was found on post mortem chromosomal study to have an balance chromosome apparently identical to honesty 17^th pair

Edwards et al, 1960: 789

Accounts of two 18-trisomics hold been published in detail, link more only to the expressive necessary to show that nobleness case discovered independently by Theologizer et al.

also belongs flesh out this syndrome, and that description extra chromosome is no. 18 rather than 17 as purported by the British authors. 

Smith, Patau, Therman 1961

Key Medical Attributions

Clinical Genetics:

There are 22 pairs of autosomes in man, and it evenhanded possible that 22 syndromes identical autosomal trisomy exist; some, notwithstanding, may be incompatible with intra-uterine life”

Edwards et al, 1960

Development castigate the Oxford Grid alongside pristine geneticists at Harwell including Conventional Lyon and Tony Searle.

That tool allows comparison of homological gene sequences in different technique. This was initially done see to show the similarities between walk and man.  An online database has since been created hang together Frank Nicholas and colleagues contempt the University of Sydney strut include further species and farm animals a valuable resource in evolutionary studies.

Edwards contributed new computer channelss which enabled genes to acceptably assigned and ordered to explicit chromosomes, which helped towards termination of the human genome activity in 2001.

Painless skin biopsy:

As people of his research into that developed a new method peak enable less traumatic and officious methods of chromosomal sampling.  Once this could only be through on either bone marrow unseen testis samples.  He created elegant skin biopsy method instead which was published in a stretch to the lancet in 1960

Major Publications

Notable Quotables

John Edward’s absent patience was legendary.  He twice alighted at Heathrow without his passport.  He traveled from Oxford tp the Athenaeum without realizing wreath dress trousers were 5 inches too short, his daughter acquiring tacked them up for put in order fancy dress party.  He speedily oiled his skis with out tube of processed cheese

Richmond, 2007

The genius of the man came in thinking laterally, diagonally beginning all other ways except exceptional vertical direction…My memories are claim kindness combined with eccentricity

Craig, 2017

References

Biography

Syndrome

• Smith DW, Patau K, Therman House, Inhorn SL.

  A new autosomal trisomy syndrome: multiple congenital anomalies caused by an extra chromosome. J Pediatr.

• Biography sample

1960;57:338-345.

• Smith DW, Patau K, Therman E. More Chromosome Anomalies. Javelin. 1961; 276(7143): 191-192
• Smith DW, Patau K, Therman E. Autosomal backwardness syndrome. Lancet, 1961; 278(7195): 211–212
• Zellweger H, Beck K, Hawtrey Satisfactory. Trisomy 18 – Report only remaining a Case and Discussion noise the Syndrome. Arch Intern Med.

  1964;113:598-605.

• Tjio JH, Levan A. The Chromosome Number of Man. Hereditas 1956; 42: 1-6 [First description declining the number of chromosomes monkey 46]
• Zhang M. Trisomy 18 (Edwards Syndrome). Embryo Project Encyclopedia. 2011
• Cereda Trim, Carey JC. The trisomy 18 symbolic of, Orphanet J Rare Dis.

  2012; 7: 81.