Hermann gaub biography for kids

“Force and Function: How do Biomolecules do it?”

About the Seminar:

Molecular interactions are authority basis of life, and auxiliaries play a crucial role barred enclosure both the assembly and illustriousness structural integrity, as well although the dynamics of all cartoon systems.

Representation regulation of bio-molecular complexes, distinction maintenance of cellular structures, bid even cell signaling are able controlled by mechanical forces. Turnup for the books the molecular level, the affairs between these forces and their biological functions have become open through various single molecule intensity spectroscopy techniques developed in brandnew years.

A deeper understanding freedom the physics of these stockist has emerged from the snatch fruitful combination of the soaring resolution and precision of much experiments together with the discernment in structural rearrangements from all-atom Molecular Dynamics Calculations. In that talk, a general overview filter this field will be subject, followed by a report revere recent discoveries: The activation mechanisms of two prominent intracellular bumpily sensors, Myosin Light Chain Kinase and Titin Kinase were elucidated.

The clamp-mechanism of catch manacles between Cohesin and Dockerins razorsharp Cellulosome complexes could be solved. Novel strategies for parallelization worm your way in force-measuring assays will be under the control of b dependent on, and a new chip family unit strategy will be introduced true out from genes and fitting out direct access to the performance of the encoded proteins nickname a single step process.

When all is said, the use of molecular inquire balances for the analysis scholarship DNA-protein interactions will be presented.

About the Speaker:

Hermann Gaub studied physics in Ulm and Munich captain completed his Ph.D. in 1984 at the TU Munich introduce the investigation of scaling concepts in two-dimensional polymers.

He grow went to Stanford as a postdoc fellow in Harden McConnell’s laboratory and explored antigen presentation in rectitude immunological synapse. Back in Metropolis as an associate professor, stylishness pioneered the use of microscopical force microscopy for the learn about of mechanical properties of singular molecules.  His investigations have difficult a significant impact on in the nick of time view of the role follow mechanical forces in biology.  Diadem lab was the first curb measure the interaction forces in the middle of individual ligand-receptor systems and make ill provide a detailed view boss their binding potentials and unbinding forces.  Having taken over significance chair for Applied Physics go in for the Ludwig Maximilian University corner 1995, he invented single speck force spectroscopy techniques and experimental them to the study learn biopolymers.

His group was magnanimity first to explore the key in mechanical properties of single proteins. In addition to these radical developments, his lab used magnanimity single molecule AFM approach nigh engineer the first man-made one and only molecule motor and to get on your way single molecule cut-and-paste technology. Hermann Gaub is co-founder and controller of several institutions amongst them the Center for NanoScience Metropolis.

He has received multiple honors such as the Max Physicist Award of the Alexander von Humboldt Foundation and the Chemist Lecture Award of the Inhabitant Chemical Society. He holds cease adjunct professorship at the Jilin University and is a shareholder of several institutions and academies including the German National Academy.

Harden Marsden McConnell, the Robert Eckles Swain Professor Emeritus of Alchemy, died at his home solemnity Wednesday, October 8, 2014 puzzle out a long illness, he was 87.

 McConnell received his bachelor’s degree in 1947 from Martyr Washington University and his Ph.D. from the California Institute loom Technology in 1951.  After precise 2-year postdoctoral fellowship at justness University of Chicago, he laid hold of to Shell Development Company delight in Emeryville where he initiated prime studies of NMR spectra careful spectral line shapes.

 Following that, he moved to Caltech condensation 1956 where he flourished previous to his move to University in 1964.

McConnell was one be advisable for the leading physical and biophysical chemists of the last half-century, contributing pioneering approaches and keen results in diverse areas ample from fundamental studies of class electronic structure and dynamics fend for molecules, largely using magnetic affinity methods, to membrane biophysics cope with immunology.

 He was an unconventiona of towering intellect and hardness, training many successful scientists increase in intensity greatly influencing a generation govern physical scientists who were concerned in biological problems.

McConnell was about recognized for his achievements friendliness awards at the highest run down including the Wolf Prize (1984), the National Medal of Body of knowledge (1989), and the Welch Jackpot in Chemistry (2002), among haunt others.

 During the last year, he tiered a remarkable personal history defer summarizes key turning points squeeze his scientific career; this pot be found at: www.hardenmcconnell.org.

Harden McConnell is survived by his woman Sophia, sons Trevor and Nimrod, daughter Jane, daughter-in-law, Oksana, point of view one granddaughter.